Organometallic Compounds
Medchemexpress LLC Tri(Amino-PEG3-amide)-amine | 2523025-40-1 | MFCD28142446 | 98.0% | C33H69N7O12 | 25 MG
Tri(Amino-PEG3-amide)-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-(Azido-PEG2)-N-bis(PEG4-Boc) | 2112731-81-2 | C36H70N4O14 | 100 MG
N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains an azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
![Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | 95.0% | 234.25 g/mol | C8H18N4O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202343.png-250.jpg)
Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | 95.0% | 234.25 g/mol | C8H18N4O4 | 5 MG
Aminooxy-PEG3-azide is a bifunctional PEG linker containing an aminooxy group and an azide handle for oxime ligation and azide-alkyne click chemistry. It is supplied as a liquid and is used for ADC and PROTAC linker synthesis, and for general bioconjugation and small-molecule assembly.
- Bifunctional: aminooxy and azide reactive groups.
- Peg3 spacer provides hydrophilicity and flexibility.
- Suitable for oxime formation with carbonyls and CuAAC click reactions.
- Purity typically 95.0%.
- Stable when stored at -20°C; in solvent short-term storage at lower temperatures recommended.
- Available in small research quantities, such as 5 mg.
Medchemexpress LLC Dbco-peg3-acid | 2754384-59-1 | 98.4% | 508.56 g/mol | C28H32N2O7 | 10 MG
DBCO-PEG3-acid is a dibenzocyclooctyne (DBCO)-containing PEG linker designed for copper-free click chemistry (strain-promoted alkyne-azide cycloaddition) in bioconjugation and antibody-drug conjugate synthesis. It is a non-cleavable linker supplied as a solid for laboratory use.
(OCC)OCC | 5g | 537719000](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502151768.JPG-250.jpg)
eMolecules 3473-76-5 | N-((Triethoxysilyl)methyl)aniline | Oakwood Chemical | MFCD08275519 | 269.416 | C13H23NO3Si | 97.000 | CCO[Si](CNc1ccccc1)(OCC)OCC | 5g | 537719000
N-((Triethoxysilyl)methyl)aniline | Oakwood Chemical | 3473-76-5 | MFCD08275519 | 269.416 | C13H23NO3Si | 97.000 | CCO[Si](CNc1ccccc1)(OCC)OCC | 5g | 537719000
Medchemexpress LLC Cytidine, 2',3'-O-(1-methylethylidene)- | 362-42-5 | >=99.0% | C12H17N3O5 | 1 G
2',3'-O-Isopropylidenecytidine is a synthetic sugar compound intended for research use only.
- Purity >=99.0%
- Appearance: Solid, white to light yellow
- Storage: Recommended storage at 4°C, protected from light; in solvent, -80°C for 6 months or -20°C for 1 month (protect from light)
Medchemexpress LLC Bromoacetamido-PEG3-C2-Boc | 1807537-33-2 | C15H28BrNO6 | 1 G
Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that is utilized in the synthesis of PROTACs. PROTACs themselves are small molecules composed of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a protein of interest. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Application: used in the synthesis of PROTACs.
- Mechanism: facilitates the degradation of target proteins via the ubiquitin-proteasome system when incorporated into PROTACs.
- Research use: for research purposes only; not intended for sale to patients.
- Form: liquid (density: 1.252 g/cm3), colorless to light yellow.
Medchemexpress LLC m-PEG5-NH2 | 5498-83-9 | 99.0% | C11H25NO5 | 250 MG
m-PEG5-NH2 is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules consisting of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These molecules function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only and not sold to patients.
- Purity: 99.02%
- Molecular weight: 251.32
- Formula: C11H25NO5
- CAS number: 5498-83-9
- Appearance: Liquid (density: 1.023±0.06 g/cm³)
- Color: Colorless to light yellow
- SMILES: COCCOCCOCCOCCOCCN
- Leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Dbco-PEG3-VC-Exatecan | 2754384-70-6 | 96.7% | 1331.44 g/mol | C71H79FN10O15 | 10 MG
DBCO-PEG3-VC-Exatecan is a drug-linker conjugate used in antibody-drug conjugate (ADC) research that couples a DBCO-functionalized PEG3 valine-citrulline cleavable linker to the topoisomerase I inhibitor exatecan.
- Provides a cleavable valine-citrulline (VC) linker for intracellular release.
- Includes a DBCO handle for strain-promoted azide-alkyne cycloaddition (click chemistry).
- Incorporates a PEG3 spacer to improve solubility and linker flexibility.
- Delivers exatecan, a DNA topoisomerase I inhibitor payload.
- High purity (~96.7%) and large molecular weight (~1331.44 g/mol).
- Soluble in DMSO at 50 mg/mL with ultrasonic assistance.
- Stored sealed at -20 °C; in solution, stable at -80 °C for 6 months and -20 °C for 1 month.
Medchemexpress LLC ABT-639 | 1235560-28-7 | 99.32% | 455.91 | 25 MG
ABT-639 | 1235560-28-7 | 99.32% | 455.91 | 25 MG
Medchemexpress LLC M-PEG3-succinimidyl carbonate | 477775-77-2 | 99.4% | C12H19NO8 | 250 MG
m-PEG3-succinimidyl carbonate is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other to the target protein. These molecules function by utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC 4,7,10,16,19,22-Hexaoxa-13-azapentacosanedioic acid, 1,25-bis(1,1-dimethylethyl) ester | 1814901-03-5 | 98.0% | C26H51NO10 | 250 MG
NH-bis(PEG3-Boc) is a PEG-based PROTAC linker. It can be used in the synthesis of PROTACs, which are molecules designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets the protein of interest.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.